1 Effect sizes correlation between SSC and SPARK

Note SNPs were ascertained based on p-values < 1e-5 in SSC and SPARK, respectively.

Overall, there is no significant correlation due to large standard errors.


2 Meta strategy

Meta-analysis was performed using inverse-variance weighted method implemented in METAL.

  • Five phenotypes are showed between SPARK and SSC, inlcuding:
    • “RBS_R_RMB_sum”, “RBS_R_SIB_sum”, “RBS_R_Compulsions_sum”, “RBS_R_IS_sum”, “RBS_R_CI_sum”
  • We performed on a total of 6,177,264 common SNPs.


2.1 Association Summary

  • Associations with marginal p-values < 1e-5 are reported.


2.2 COJO summary

  • GCTA COJO was performed to identify additional significant signals at p-value < 5e-8 and 1e-6.
  • No signals were identified at p-value < 5e-8.
  • 5 signals were identified at p-value < 1e-6.
    • 3 signals were detected for RBS_R_CI_sum and 1 for RBS_R_RMB_sum and RBS_R_SIB_sum, respectively


2.3 QQ plot